Reference Centre for Inherited Metabolic Disorders (MaMEA) and IMAGINE Institiute, Necker-Enfants Malades Hospital, 149 Rue de Sevres, 75743, Paris, Cedex 15, France. vassili.valaya@nck.aphp.fr. Reference Center for Metabolic Diseases, Pediatric Neurology & Metabolic diseases, Robert Debre University Hospital, Paris, France. Unidad de Nutrición y Metabolismo, Hospital Infantil Sevilla, Sevilla, Spain. Centre de Référence des Maladies Héréditaires du Métabolisme, CHU Timone Enfants, Marseille, France. Complejo Hospitalario Universitario de Santiago de Compostela (CHUS), Santiago de Compostela, Spain. Servicio de Neurologíia Infantil, Hospital Vall d'Hebrón, Barcelona, Spain. Reference Center for Inherited Metabolic and Muscular Disease AOU, Meyer, Firenze, Italy. Hospital Sant Joan de Déu and CIBER-ER, Instituto de Salud Carlos III, Barcelona, Spain. Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. Hospital Clínico Universitario de Salamanca, UCI Pediátricia, Salamanca, Spain. Reference Centre of Inherited Metabolic Disorders, Femme Mère Enfant Hospital, Lyon, France. Department of Metabolic Diseases, Wilhelmina Children's Hospital, Utrecht, The Netherlands. Department of Pediatric Metabolism and Nutrition, Ege University Medical Faculty, Izmir, Turkey. Hospital Infantil Universitario La Paz, Madrid, Spain. Unidad Enfermedades Metabólicas Servicio de Pediatria, Hospital Universitario Ramón Y Cajal Ctra, Madrid, Spain. Unidad de Cuidados Intensivos Pediáticos, Hospital Clinic Universitario de Valencia, UCI Neonatal, Valencia, Spain. UOC of Metabolic and Genetic Diseases, Children's Hospital Giovanni XXIII, Bari, Italy. Medical Affairs, Orphan Europe, Paris, France.